It is well known that women age is important for reproduction. The female biological clock is well-defined temporally and biologically, with declining oocyte production when the woman is in her late 30s or early 40s and cessation of menses in the late 40s and early 50s. Whereas woman’s chances to conceive naturally drop sharply, male fertility does not cease abruptly, since androgen production and spermatogenesis continue throughout life. There are some worldwide-known examples of famous personalities who fathered children at an advanced age, like Julio Iglesias´s senior (90), Luciano Pavarotti (68) or Rod Stewart (66).
A great problem in our society and that of industrialized countries is that couples wait longer to have children, and advances in reproductive technology currently allow older men and women to consider being parents. However, many studies highlight age as an important factor to conceive in both sexes. During years, fertility research has focused mainly on women age, and so potential adverse effects of male age might have passed unnoticed. However, there is currently great concern about the decreasing quality of sperm with age in men. In 2010, the World Health Organisation (WHO) changed criteria to semen evaluation, due to a decreased concentration and normal sperm morphology below the threshold for which a semen sample was considered of good quality.
IS AGE IN MEN ASSOCIATED WITH DIFFERENT OFFSPRING DISEASES OR LIVE BIRTH RATES?
These alterations could explain the association of paternal age with the increased incidence of some psychiatric disorders such as those of the autism spectrum, psychosis, schizophrenia and bipolar disorders at childbearing. Moreover, there seems to be supporting evidence that paternal age significantly influences the incidence of having a child with Down syndrome when combined with maternal age. This could also be the case for other genetic abnormalities, which could in turn lead to miscarriage or different diseases in the newborns.
Finally, It has been demonstrated that men over 35 years old are twice as likely to be infertile (defined as the inability to achieve a pregnancy within 12 months).
In summary, age is an important factor both in women and in men, but It should also be taken into consideration that there are other factors such as obesity, habitual alcohol and/or tobacco intake and stress, among other well-studied elements, which might be effectively altering our fertility potential.
Currently available data not only show that male biological clock does exist, but it is also important to fertility. Mechanisms of action are unclear, but as above-exposed, they might involve impaired semen parameters and increased levels of damaged sperm DNA, which could affect fertilization, implantation and even embryo development.
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